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IRAK1BP1 Rabbit anti-Human, Polyclonal, Bioss
SDP

Rabbit Polyclonal Antibody

Supplier:  Bioss BS16694R

Encompass_Preferred

Catalog No. 50-198-4007


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Description

Description

SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.
Specifications

Specifications

IRAK1BP1
Polyclonal
Unconjugated
IRAK1BP1
4921528N06Rik; Aabp3; Acta binding protein 3; ActA-binding protein 70; AI851240; Aip70; interleukin 1 receptor associated kinase 1 binding protein 1; interleukin-1 receptor-associated kinase 1 binding protein 1; Interleukin-1 receptor-associated kinase 1-binding protein 1; IRAK1-binding protein 1; Irak1bp1; MGC138458; MGC138460; PLK-interacting protein; Signaling molecule that associates with the mouse pelle-like kinase; Simpl
Rabbit
Protein A
RUO
134728
-20°C
Liquid
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 μg/mL
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Q5VVH5
IRAK1BP1
KLH conjugated synthetic peptide derived from human IRAK1BP1.
100 μL
Primary
Human
Antibody
IgG
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