Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. 501984007

IRAK1BP1 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501984007
Encompass_Preferred
Change view
Click to view available options
Quantity:
100 μL
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
50-198-4007 100 μL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. 50-198-4007 Supplier Bioss Supplier No. BS16694R
Add to Cart
Add to Cart

Description

Rabbit Polyclonal Antibody

SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.

Specifications

Antigen IRAK1BP1
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene IRAK1BP1
Gene Accession No. Q5VVH5
Gene Alias 4921528N06Rik; Aabp3; Acta binding protein 3; ActA-binding protein 70; AI851240; Aip70; interleukin 1 receptor associated kinase 1 binding protein 1; interleukin-1 receptor-associated kinase 1 binding protein 1; Interleukin-1 receptor-associated kinase 1-binding protein 1; IRAK1-binding protein 1; Irak1bp1; MGC138458; MGC138460; PLK-interacting protein; Signaling molecule that associates with the mouse pelle-like kinase; Simpl
Gene Symbols IRAK1BP1
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human IRAK1BP1.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 134728
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.