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IRAK2 Mouse anti-Human, Clone: OTI1D4, lyophilized, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene CF803679

Encompass_Preferred

Catalog No. 50-166-6625


May include imposed supplier surcharges.
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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

IRAK2 (interleukin-1 receptor-associated kinase-like 2) binds to the IL-1 type I receptor following IL-1 engagment and triggers intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappa-B , which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kappa-B activation. IRAKs also associate with Toll-like receptor (TLR) and the domit negative mutants of IRAKs inhibit LPS-induced NF-kappa-B activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory responses to cytokine IL-1 and LPS. IRAK2 is expressed in a variety of human tissues.
Specifications

Specifications

IRAK2
Monoclonal
Unconjugated
IRAK2
IRAK-2
Mouse
Affinity Chromatography
RUO
3656
-20° C, Avoid Freeze/Thaw Cycles
Lyophilized
Western Blot
OTI1D4
PBS with 8% trehalose and no preservative; pH 7.3
O43187
IRAK2
Human recombit protein fragment corresponding to amino acids 362-625 of human IRAK2 produced in E.coli.
100 μg
Primary
Human
Antibody
IgG1
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