Learn More
IRAK2 Mouse anti-Human, Clone: OTI1D4, lyophilized, TrueMAB™

Mouse Monoclonal Antibody
Supplier: OriGene CF803679

Description
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO
IRAK2 (interleukin-1 receptor-associated kinase-like 2) binds to the IL-1 type I receptor following IL-1 engagment and triggers intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappa-B , which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kappa-B activation. IRAKs also associate with Toll-like receptor (TLR) and the domit negative mutants of IRAKs inhibit LPS-induced NF-kappa-B activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory responses to cytokine IL-1 and LPS. IRAK2 is expressed in a variety of human tissues.Specifications
IRAK2 | |
Monoclonal | |
Unconjugated | |
IRAK2 | |
IRAK-2 | |
Mouse | |
Affinity Chromatography | |
RUO | |
3656 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Western Blot | |
OTI1D4 | |
PBS with 8% trehalose and no preservative; pH 7.3 | |
O43187 | |
IRAK2 | |
Human recombit protein fragment corresponding to amino acids 362-625 of human IRAK2 produced in E.coli. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG1 |
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.