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IRAK2 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501983233
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50-198-3233 100 μL
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Catalog No. 50-198-3233 Supplier Bioss Supplier No. BS1427R
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Description

Rabbit Polyclonal Antibody

IRAK2 (interleukin-1 receptor-associated kinase-like 2) binds to the IL-1 type I receptor following IL-1 engagment and triggers intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappa-B , which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kappa-B activation. IRAKs also associate with Toll-like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kappa-B activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory responses to cytokine IL-1 and LPS. IRAK2 is expressed in a variety of human tissues.

Specifications

Antigen IRAK2
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene IRAK2
Gene Accession No. O43187
Gene Alias 6330415L08Rik; AI649099; interleukin 1 receptor associated kinase 2; interleukin-1 receptor associated kinase-2; interleukin-1 receptor-associated kinase 2; interleukin-1 receptor-associated kinase 2c; Interleukin-1 receptor-associated kinase-like 2; Irak2; IRAK-2; MGC150550; mu-IRAK-2
Gene Symbols IRAK2
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human IRAK2.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3656
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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