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Tocris Bioscience™ IRAK3 Degrader 23
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Catalog No. 79835
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79-835 5 mg
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Catalog No. 79-835 Supplier Tocris Bioscience™ Supplier No. 7983/5
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Description

IRAK3 PROTAC™ Degrader

IRAK3 Degrader 23 is a potent and selective IRAK3 PROTAC™ Degrader (DC50 = 2 nM; Dmax = 98% in THP1 cells and primary macrophages), requires CRBN and IRAK3 binding for Degrader activity. Also inhibits CDK11, CDK8, TRKC and GSG2 (IC50 values are 16 nM, 36 nM, 100 nM and 110 nM respectively).PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Chemical Name or Material 2-(2,6-Dioxo-3-piperidyl)-5-[4-[2-[1-[4-[4-[cis-4-[(5-isopropylpyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]cyclohexyl]-piperazin-1-yl]-4-oxo-butanoyl]-4-piperidyl]ethyl]piperazin-1-yl]-isoindoline-1,3-dione
CAS 2712600-00-3
Quantity 5 mg
Target Active Degraders
Molecular Formula C47H63N11O6
Purity 0.98
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