Invitrogen™ IRAK4 Monoclonal Antibody (2H9)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA515883

Catalog No. PIMA515883

Description

MA5-15883 targets IRAK4 in indirect ELISA, FACS, IHC, and WB applications and shows reactivity with Human, mouse, and Non-human primate samples. The MA5-15883 immunogen is purified recombinant fragment of human IRAK4 expressed in E. Coli. . MA5-15883 detects IRAK4 which has a predicted molecular weight of approximately 52kDa.

IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. Overexpression of IRAK-4 activates NF-kappa-B and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.

Specifications

• Antigen: IRAK4
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: Ascites with 0.03% sodium azide
• Gene Accession No.: Q8R4K2, Q9NWZ3
• Gene Symbols: IRAK4
• Immunogen: Purified recombinant fragment of human IRAK4 expressed in E. Coli.
• Regulatory Status: RUO
• Gene ID (Entrez): 266632, 51135
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Clone: 2H9
• Conjugate: Unconjugated
• Gene: IRAK4
• Gene Alias: 8430405M07Rik; 9330209D03Rik; interleukin 1 receptor associated kinase 4; interleukin-1; interleukin-1 receptor-associated kinase 4; IPD1; Irak4; IRAK-4; NY-REN-64; REN64; renal carcinoma antigen NY-REN-64
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Monkey
• Product Type: Antibody
• Isotype: IgG1