Invitrogen™ IREB2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5117042

Catalog No. PIPA5117042

Description

Positive Samples: 293T, Mouse kidney, Rat liver Immunogen sequence: SIARNSAAAK YLTNRGLTPR EFNSYGARRG NDAVMTRGTF ANIKLFNKFI GKPAPKTIHF PSGQTLDVFE AAELYQKEGI PLIILAGKKY GSGNSRDWAA KGPYLLGVKA VLAESYEKIH KDHLIGIGIA PLQFLPGENA DSLGLSGRET FSLTFPEELS PGITLNIQTS TGKVFSVIAS FEDDVEITLY KHGGLLNFVA RKFS.

Iron regulatory protein 2 (IRP2) is a central post-transcriptional regulator of cellular and systemic iron metabolism. It is a cytosolic RNA-binding protein that binds to stem-loop structures. IRP2 is regulated by iron-mediated proteolysis. Hypoxia is important for normal tissue physiology as well as being a component of several pathophysiological conditions, including heart and cerebrovascular diseases and tumor growth. Because iron and oxygen are closely related, IRP2 also plays a role during hypoxia (low oxygen).

Specifications

• Antigen: IREB2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IREB2
• Gene Alias: ACO3; D9Ertd85e; FLJ23381; im:7153062; Ireb2; IRE-BP 2; IREBP2; Iron regulatory protein 2; iron responsive element binding protein 2; iron-regulatory protein 2; iron-responsive element binding protein 2; iron-responsive element-binding protein 2; Iron-responsive element-binding protein 2-like protein; IRP2; IRP2AD
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3658, 64602, 64831
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 2.06 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P48200, Q62751, Q811J3
• Gene Symbols: IREB2
• Immunogen: Recombinant protein (or fragment).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG