IRF1 Mouse anti-Human, PE, Clone: 20/IRF-1, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 566322
The 20/IRF-1 monoclonal antibody specifically binds to Interferon regulatory factor 1 (IRF1). IRF1 belongs to the human IRF family of transcription factors that contains nine members, IRF1-9. IRF1 is broadly expressed and its levels are upregulated in response to certain cytokines, interferons, bacterial or viral infections. IRF1 binds to specific DNA motifs such as IFN-stimulated response elements (ISRE) and regulates the activity of IFN-responsive genes. IRF1 plays roles in inflammation as well as innate and adaptive immune responses. It is involved in the regulation of cellular proliferation, Major Histocompatibility Complex (MHC) antigen expression, and the differentiation and effector functions of macrophages, dendritic cells, natural killer (NK) cells, and various T cell subsets. In addition, IRF1 may function as a tumor suppressor, since deletions in the IRF1 locus is associated with myelodysplasia and leukemias.R-phycoerythrin (PE) is an accessory photosynthetic pigment found in red algae. It exists in vitro as a 240-kDa protein with 23 phycoerythrobilin chromophores per molecule. This makes PE one of the brightest fluorochromes for flow cytometry applications, but its photobleaching properties make it unsuitable for fluorescence microscopy.
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Interferon regulatory factor 1, IRF-1, MAR|
|Human IRF1 aa. 159-279|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok