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IRF3 Mouse anti-Human, Clone: OTI8G9, lyophilized, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner CF809316

Catalog No. 50-166-9408


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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

IRF-3 is encoded by the IRF-3 gene located on chromosome 19 in humans and belongs to the Interferon regulatory transcription factor (IRF) family. IRF-3 plays a critical role in the response of the immune system to viral infection. It binds to the Interferon stimulated response element (ISRE) of its downstream target genes such as Interferon alpha and beta to activate their transcription which eventually leads to immune modulatory actions of the type I Interferon (IFN) pathway. Following phosphorylation on Serine 396, IRF-3 has been shown to affiliate with CREB binding protein (CREBBP) and translocate to the nucleus which is critical for its ability to bind to DNA and act as a transcription factor. Additionally, phosphorylation associated nuclear translocation may also protect IRF-3 from degradation by the virus machinery.
Specifications

Specifications

IRF3
Monoclonal
Unconjugated
IRF3
Lyophilized
IRF3
Human recombit protein fragment corresponding to amino acids 27-169 of human IRF3 produced in E.coli.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Western Blot
OTI8G9
PBS with 8% trehalose and no preservative; pH 7.3
Q14653
IIAE7
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
3661
SDS
Documents
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