IRF3 Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc IHC00169

Catalog No. 50-157-1611

Description

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Orangutan

IRF-3 is encoded by the IRF-3 gene located on chromosome 19 in humans and belongs to the Interferon regulatory transcription factor (IRF) family. IRF-3 plays a critical role in the response of the immune system to viral infection. It binds to the Interferon stimulated response element (ISRE) of its downstream target genes such as Interferon alpha and beta to activate their transcription which eventually leads to immune modulatory actions of the type I Interferon (IFN) pathway. Following phosphorylation on Serine 396, IRF-3 has been shown to affiliate with CREB binding protein (CREBBP) and translocate to the nucleus which is critical for its ability to bind to DNA and act as a transcription factor. Additionally, phosphorylation associated nuclear translocation may also protect IRF-3 from degradation by the virus machinery.

Specifications

• Antigen: IRF3
• Classification: Polyclonal
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene Accession No.: Q14653
• Gene Symbols: IRF3
• Immunogen: Between 100 and 150
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry
• Conjugate: Unconjugated
• Gene: IRF3
• Gene Alias: IRF-3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3661
• Content And Storage: 4° C
• Form: Liquid