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Invitrogen™ IRF4 Monoclonal Antibody (SP114)
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Catalog No. PIMA516382
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500 μL
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PIMA516382 500 μL
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Catalog No. PIMA516382 Supplier Invitrogen™ Supplier No. MA516382
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Description

Rabbit Monoclonal Antibody

Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM EDTA buffer for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is Hodgkin's lymphoma.

The IRF (interferon regulatory factor) family of transcription factors are characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. IRF4 is lymphocyte specific and negatively regulates toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IRF4
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone SP114
Concentration 0.102 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA and 0.1% sodium azide; pH 7.6
Gene IRF4
Gene Accession No. Q15306
Gene Alias AI385587; interferon regulatory factor 4; Irf4; IRF-4; LSIRF; Lymphocyte-specific interferon regulatory factor; multiple myeloma oncogene 1; MUM1; NF-EM5; PU.1 interaction partner; Sfpi1/PU.1 interaction partner; SHEP8; Spip; Transcriptional activator PIP
Gene Symbols IRF4
Host Species Rabbit
Immunogen A synthetic peptide near C-terminus of human MUM1/IRF4.
Purification Method Protein A/G
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3662
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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