Invitrogen™ IRF4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587447

Catalog No. PIPA587447

Description

Immunogen sequence: HPYTMTTPYP SLPAQQVHNY MMPPLDRSWR DYVPDQPHPE IPYQCPMTFG PRGHHWQGPA CENGCQVTGT FYACAPPESQ APGVPTEPSI RSAEALAFSD CRLHICLYYR EILVKELTTS SPEGCRISHG HTYDASNLDQ VLFPYPEDNG QRKNIEKLLS HLERGVVLWM APDGLYAKRL CQSRIYWDGP LALCNDRPNK L; Positive Samples: Mouse spleen, Mouse lung, Rat spleen, Rat lung, Rat thymus; Cellular Location: Nucleus.

The IRF (interferon regulatory factor) family of transcription factors are characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. IRF4 is lymphocyte specific and negatively regulates toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found.

Specifications

• Antigen: IRF4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IRF4
• Gene Alias: AI385587; interferon regulatory factor 4; Irf4; IRF-4; LSIRF; Lymphocyte-specific interferon regulatory factor; multiple myeloma oncogene 1; MUM1; NF-EM5; PU.1 interaction partner; Sfpi1/PU.1 interaction partner; SHEP8; Spip; Transcriptional activator PIP
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16364, 3662
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.57 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q15306, Q64287
• Gene Symbols: IRF4
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 150-350 of human IRF4 (NP_0024512).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG