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Invitrogen™ IRF4 Recombinant Rabbit Monoclonal Antibody (RM352)
Rabbit Recombinant Monoclonal Antibody
Supplier: Invitrogen™ MA533088
Description
Specificity: reacts to human MUM1/IRF4 (Multiple myeloma oncogene 1) (Interferon regulatory factor 4). Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
The IRF (interferon regulatory factor) family of transcription factors are characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. IRF4 is lymphocyte specific and negatively regulates toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found.
Specifications
IRF4 | |
Recombinant Monoclonal | |
0.1 mg/mL | |
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide | |
Q15306 | |
IRF4 | |
A peptide corresponding to the C-terminus of human MUM1/IRF4. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Immunohistochemistry (Paraffin), Western Blot | |
RM352 | |
Unconjugated | |
IRF4 | |
AI385587; interferon regulatory factor 4; Irf4; IRF-4; LSIRF; Lymphocyte-specific interferon regulatory factor; multiple myeloma oncogene 1; MUM1; NF-EM5; PU.1 interaction partner; Sfpi1/PU.1 interaction partner; SHEP8; Spip; Transcriptional activator PIP | |
Rabbit | |
Protein A | |
RUO | |
3662 | |
-20°C | |
Liquid |
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