Invitrogen™ IRF8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA589354

Catalog No. PIPA589354

Description

Immunogen sequence: ECGRSEIDEL IKEPSVDDYM GMIKRSPSPP EACRSQLLPD WWAQQPSTGV PLVTGYTTYD AHHSAFSQMV ISFYYGGKLV GQATTTCPEG CRLSLSQPGL PGTKLYGPEG LELVRFPPAD AIPSERQRQV TRKLFGHLER GVLLHSSRQG VFVKRLCQGR VFCSGNAVVC KGRPNKLERD EVVQVFDTSQ FFRELQQFYN SQGRLPDGRV VLCFGEEFPD MAPLRSKLIL VQIEQLYVRQ LAEEAGKSCG AGSVMQAPEE PPPDQVFRMF PDICASHQRS FFRENQQITV; Positive Samples: THP-1; Cellular Location: Nucleus.

IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.

Specifications

• Antigen: IRF8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Irf8
• Gene Alias: AI893568; H-ICSBP; Icsbp; Icsbp1; IMD32A; IMD32B; interferon consensus sequence binding protein 1; Interferon consensus sequence-binding protein; Interferon regulatory factor 8; Irf8; IRF-8; Myls; transcription factor ICSBP
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3394
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.36 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q02556
• Gene Symbols: Irf8
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 137-426 of human IRF8 (NP_0021541).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG