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Invitrogen™ IRF8 Polyclonal Antibody
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Catalog No. PIPA589354
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100 μL
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PIPA589354 100 μL
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Catalog No. PIPA589354 Supplier Invitrogen™ Supplier No. PA589354
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ECGRSEIDEL IKEPSVDDYM GMIKRSPSPP EACRSQLLPD WWAQQPSTGV PLVTGYTTYD AHHSAFSQMV ISFYYGGKLV GQATTTCPEG CRLSLSQPGL PGTKLYGPEG LELVRFPPAD AIPSERQRQV TRKLFGHLER GVLLHSSRQG VFVKRLCQGR VFCSGNAVVC KGRPNKLERD EVVQVFDTSQ FFRELQQFYN SQGRLPDGRV VLCFGEEFPD MAPLRSKLIL VQIEQLYVRQ LAEEAGKSCG AGSVMQAPEE PPPDQVFRMF PDICASHQRS FFRENQQITV; Positive Samples: THP-1; Cellular Location: Nucleus.

IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IRF8
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.36 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Irf8
Gene Accession No. Q02556
Gene Alias AI893568; H-ICSBP; Icsbp; Icsbp1; IMD32A; IMD32B; interferon consensus sequence binding protein 1; Interferon consensus sequence-binding protein; Interferon regulatory factor 8; Irf8; IRF-8; Myls; transcription factor ICSBP
Gene Symbols Irf8
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 137-426 of human IRF8 (NP_0021541).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3394
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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