IRF8 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA124478

Catalog No. PIPA124478

Description

PA1-24478 detects Interferon regulatory factor 8 (IRF8) in human samples. PA1-24478 has been successfully used in immunohistochemistry (paraffin) and Western Blot procedures. By Western blot, PA1-24478 is specific for the ∽48 kDa Interferon regulatory factor 8 (IRF8) protein. The PA1-24478 immunogen corresponds to a synthetic peptide corresponding to a region of human IRF8. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.

Specifications

• Antigen: IRF8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene Accession No.: Q02556
• Gene Symbols: IRF8
• Immunogen: Synthetic peptide corresponding to a region of human IRF8.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Gene: IRF8
• Gene Alias: H-ICSBP, ICSBP, ICSBP1, IRF-8
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3394
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid