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IRF8 Rabbit anti-Mouse, Polyclonal, Bethyl Laboratories

Catalog No. 501566705
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50-156-6705 100 μL
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Catalog No. 50-156-6705 Supplier Bethyl Laboratories, Inc Supplier No. A304028A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.

Specifications

Antigen IRF8
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene Irf8
Gene Accession No. P23611
Gene Alias H-ICSBP, ICSBP, ICSBP1, IRF-8
Gene Symbols Irf8
Host Species Rabbit
Immunogen Between 374 and 424
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15900
Target Species Mouse
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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