IRF8 Rabbit anti-Human, Polyclonal, Proteintech

Catalog No.	Quantity
50-173-4360	150 μL

Catalog No. 50-173-4360 Supplier Proteintech Group Inc Supplier No. 244371AP150UL

Description

Rabbit Polyclonal Antibody

This antibody specifically recognizes the 48 kDa IRF8 protein.

IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.

Specifications

• Antigen: IRF8
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.34 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene: IRF8
• Gene Accession No.: Q02556
• Gene Alias: H ICSBP, ICSBP, ICSBP1, interferon regulatory factor 8, IRF 8, IRF8
• Gene Symbols: IRF8
• Host Species: Rabbit
• Immunogen: IRF8 Fusion Protein Ag19909
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3394
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG