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Invitrogen™ IRF9 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA540357

Catalog No. PIPA540357


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Description

Description

Peptide sequence: PWKHAGKQDF REDQDAAFFK AWAIFKGKYK EGDTGGPAVW KTRLRCALNK Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%.

Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. [UniProt].
TRUSTED_SUSTAINABILITY
Specifications

Specifications

IRF9
Polyclonal
Unconjugated
IRF9
gamma 48kDa; IFN alpha responsive transcription factor subunit; IFN-alpha-responsive transcription factor subunit; interferon dependent positive acting transcription factor 3 gamma; interferon regulatory factor 9; Interferon-stimulated gene factor 3 gamma; interferon-stimulated transcription factor 3; interferon-stimulated transcription factor 3, gamma (48kD); interferon-stimulated transcription factor 3, gamma 48kDa; IRF9; Irf-9; ISGF3; ISGF-3 gamma; ISGF3 p48 subunit; ISGF3G; p48; transcriptional regulator ISGF3 subunit gamma; Unknown (protein for MGC:126912); Unknown (protein for MGC:92097); zgc:92097
Rabbit
Affinity Chromatography
RUO
10379
-20°C, Avoid Freeze/Thaw Cycles
Liquid
Immunohistochemistry, Western Blot, Surface Plasmon Resonance
0.5 mg/mL
PBS with 2% sucrose and 0.09% sodium azide
Q00978
IRF9
Synthetic peptide directed towards the N-terminal of human ISGF3G (aa 41-90).
100 μL
Primary
Human
Antibody
IgG
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