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Invitrogen™ IRGM Polyclonal Antibody
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Catalog No. PIPA520508
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100 μg
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PIPA520508 100 μg
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Catalog No. PIPA520508 Supplier Invitrogen™ Supplier No. PA520508
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Description

Rabbit Polyclonal Antibody

A suggested positive control is human brain tissue lysate. PA5-20508 can be used with blocking peptide PEP-0628.

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway and being significantly associated with Crohn's disease. In mouse, IRGM belongs to a family of -gamma-interferon-induced GTP-binding proteins of approximately 48 kDa. Murine IRGM induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. Human IRGM is also involved in autophagy and plays a role in the control of intracellular pathogens and in the reduction of intracellular bacillary load.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IRGM
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene IRGM
Gene Accession No. A1A4Y4, Q60766, Q6AYC2
Gene Alias Ifggd3; Ifi1; Iigp3; Iipg3; immunity related GTPase M; immunity related GTPase m1; immunity-related GTPase family M member 1; immunity-related GTPase family M protein; Immunity-related GTPase family M protein 1; immunity-related GTPase family, M; immunity-related GTPase family, M1; immunity-related GTPase M; interferon inducible protein 1; interferon-gamma-inducible GTPase Ifggd3 protein; interferon-inducible GTPase 3; Interferon-inducible protein 1; Irgm; Irgm1; LPS-stimulated RAW 264.7 macrophage protein 47; LPS-stimulated RAW 264.7 macrophage protein 47 homolog; LRG 47; LRG47; LRG-47; LRG-47-like protein; MGC149263
Gene Symbols IRGM, Irgm1
Host Species Rabbit
Immunogen A 14 amino acid peptide near the center of the human IRGM.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15944, 303090, 345611
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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