IRGM Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-5836	100 μL

Catalog No. 50-198-5836 Supplier Bioss Supplier No. BS4015R

Description

Rabbit Polyclonal Antibody

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway and being significantly associated with Crohn′s disease. In mouse, IRGM belongs to a family of -gamma-interferon-induced GTP-binding proteins of approximately 48 kDa. Murine IRGM induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. Human IRGM is also involved in autophagy and plays a role in the control of intracellular pathogens and in the reduction of intracellular bacillary load.

Specifications

• Antigen: IRGM
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: IRGM
• Gene Accession No.: A1A4Y4
• Gene Alias: Ifggd3; Ifi1; Iigp3; Iipg3; immunity related GTPase M; immunity related GTPase m1; immunity-related GTPase family M member 1; Immunity-related GTPase family M protein; Immunity-related GTPase family M protein 1; immunity-related GTPase family, M; immunity-related GTPase family, M1; immunity-related GTPase M; interferon inducible protein 1; interferon-gamma-inducible GTPase Ifggd3 protein; Interferon-inducible GTPase 3; Interferon-inducible protein 1; Irgm; Irgm1; LPS-stimulated RAW 264.7 macrophage protein 47; LPS-stimulated RAW 264.7 macrophage protein 47 homolog; LRG 47; LRG47; LRG-47; LRG-47-like protein; MGC149263
• Gene Symbols: IRGM
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human IRGM .
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 345611
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG