Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Invitrogen™ IRS1 Recombinant Rabbit Monoclonal Antibody (SD2046)
Rabbit Recombinant Monoclonal Antibody
Supplier: Invitrogen™ MA542452
This item is not returnable.
View return policy
Description
Positive Control: SW480, Hela, MCF-7, human breast carcinoma tissue. Subcellular Location: Cytoplasm, Nucleus.
IRS-1, a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4). IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues. An insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. Thr 502 is identified as the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser 99 is an additional phosphorylation site catalyzed by casein kinase II. Thus, casein kinase II-catalyzed phosphorylation of IRS-1 may be a component of the intracellular insulin signaling cascade. IRS-1 contains three putative binding sites for 14-3-3 (Ser 270, Ser 374 and Ser 641) and the motif around Ser 270 is located in the phosphortyrosine binding domain of IRS-1, which is responsible for the interaction with the insulin receptor.
Specifications
IRS1 | |
Recombinant Monoclonal | |
1 mg/mL | |
TBS with 40% glycerol and 0.05% sodium azide; pH 7.4 | |
P35568 | |
IRS1 | |
Synthetic peptide within human irs1 aa 1160-1242. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
SD2046 | |
Unconjugated | |
IRS1 | |
G972R; HIRS-1; Insulin receptor substrate 1; IRS1; IRS-1; IRS1IRM; pp185 | |
Rabbit | |
Protein A | |
RUO | |
3667 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction