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Invitrogen™ IRS1 Recombinant Rabbit Monoclonal Antibody (SD2046)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA542452

Catalog No. PIMA542452


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Description

Description

Positive Control: SW480, Hela, MCF-7, human breast carcinoma tissue. Subcellular Location: Cytoplasm, Nucleus.

IRS-1, a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4). IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues. An insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. Thr 502 is identified as the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser 99 is an additional phosphorylation site catalyzed by casein kinase II. Thus, casein kinase II-catalyzed phosphorylation of IRS-1 may be a component of the intracellular insulin signaling cascade. IRS-1 contains three putative binding sites for 14-3-3 (Ser 270, Ser 374 and Ser 641) and the motif around Ser 270 is located in the phosphortyrosine binding domain of IRS-1, which is responsible for the interaction with the insulin receptor.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

IRS1
Recombinant Monoclonal
1 mg/mL
TBS with 40% glycerol and 0.05% sodium azide; pH 7.4
P35568
IRS1
Synthetic peptide within human irs1 aa 1160-1242.
100 μL
Primary
Human
Antibody
IgG
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
SD2046
Unconjugated
IRS1
G972R; HIRS-1; Insulin receptor substrate 1; IRS1; IRS-1; IRS1IRM; pp185
Rabbit
Protein A
RUO
3667
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
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