MilliporeSigma™ IRX-3, Rabbit, Unlabeled, Polyclonal,

Catalog No.	Quantity	Conjugate
ABS1050MI	100 μL	Unconjugated

Catalog No. ABS1050MI Supplier MilliporeSigma™ Supplier No. ABS1050

Description

Rabbit Polyclonal Antibody

Iroquois-class homeodomain protein IRX-3 (UniProt P81067; also known as Homeodomain protein IRXB1, Iroquois homeobox protein 3) is encoded by the Irx3 (also known as Irxb1) gene (Gene ID 16373) in murine species. Iroquois homeobox (Irx) genes encode a family of homeodomain transcription factors that are conserved from worms to vertebrates. Six IRX genes are located in two clusters in human (IRXA and IRXB) and mouse (IrxA and IrxB) genomes. Irx3 and Irx5 of the IrxB cluster are expressed in the developing mouse limb bud and are essential for proximal and anterior skeletal formation. Irx3 and Irx5 are required to establish early anteroposterior (AP) polarity and specify the anterior progenitor population. Individual Irx genes are also important for certain postnatal cardiac functions in the developing mouse heart, including cardiac repolarization (Irx5) and rapid ventricular conduction (Irx3). Postnatal deletion of Irx3 and Irx5 in the myocardium leads to prolongation of atrioventricular conduction, due in part to activation of expression of the Na(+) channel protein Nav1.5. However, combined postnatal loss of Irx3 and Irx5 results in a restoration of the repolarization gradient that is altered in Irx5 mutant hearts, suggesting that postnatal Irx3 activity can be repressed by Irx5 in mice.

Specifications

• Antigen: IRX-3
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: Please refer to lot specific datasheet.
• Conjugate: Unconjugated
• Formulation: Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
• Gene: Irx3, Irxb1
• Gene Accession No.: P81067
• Host Species: Rabbit
• Immunogen: Recombinant murine IRX-3/IRXB1 C-terminal fragment.
• Purification Method: Unpurified
• Quantity: 100 μL
• Regulatory Status: RUO
• Research Discipline: Signaling
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_001240751
• Test Specificity: Expected to react with both spliced isoforms of murine IRX-3/IRXB1 reported by UniProt (P81067).
• Target Species: Mouse
• Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
• Form: Serum

For Research Use Only. Not for use in diagnostic procedures.