Invitrogen™ ISL2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5101232

Catalog No. PIPA5101232

Description

Antibody detects endogenous levels of total ISL2.

ISL LIM Homeobox 2 (ISL2) is a gene located on chromosome 15q23 that encodes a transcription factor belonging to the LIM-homeodomain family. These transcription factors play critical roles in the regulation of gene expression during embryonic development, particularly in the differentiation and maintenance of neuronal and pancreatic cell lineages. ISL2 is specifically involved in the development of the nervous system, where it contributes to motor neuron differentiation and connectivity, as well as in the development of certain retinal structures. The protein functions by binding to specific DNA sequences, thereby influencing the transcription of target genes essential for cellular differentiation and identity. Although less studied than its paralog ISL1, ISL2's expression and roles in developmental pathways are crucial for proper organogenesis and tissue specification. Dysregulation of ISL2 has potential implications in developmental disorders and diseases involving neural and pancreatic tissues. Ongoing research aims to further elucidate its functions and potential as a therapeutic target in developmental biology and disease.

Specifications

• Antigen: ISL2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ISL2
• Gene Alias: 3110001N10Rik; Insulin gene enhancer protein ISL-2; insulin related protein 2 (islet 2); ISL LIM homeobox 2; ISL2; Isl-2; ISL2 transcription factor, LIM/homeodomain, (islet-2); islet 2; islet-2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 104360, 57233, 64843
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P50480, Q96A47, Q9CXV0
• Gene Symbols: ISL2
• Immunogen: A synthesized peptide derived from human ISL2(Accession Q96A47), corresponding to amino acid residues A164-P214.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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