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Invitrogen™ ISL2 Polyclonal Antibody
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Catalog No. PIPA541670
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100 μL
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PIPA541670 100 μL
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Catalog No. PIPA541670 Supplier Invitrogen™ Supplier No. PA541670
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Description

Rabbit Polyclonal Antibody

Peptide sequence: MDSPCQPQPL SQALPQLPGS SSEPLEPEPG RARMGVESYL PCPLLPSYHC Sequence homology: Cow: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 85%.

ISL LIM Homeobox 2 (ISL2) is a gene located on chromosome 15q23 that encodes a transcription factor belonging to the LIM-homeodomain family. These transcription factors play critical roles in the regulation of gene expression during embryonic development, particularly in the differentiation and maintenance of neuronal and pancreatic cell lineages. ISL2 is specifically involved in the development of the nervous system, where it contributes to motor neuron differentiation and connectivity, as well as in the development of certain retinal structures. The protein functions by binding to specific DNA sequences, thereby influencing the transcription of target genes essential for cellular differentiation and identity. Although less studied than its paralog ISL1, ISL2's expression and roles in developmental pathways are crucial for proper organogenesis and tissue specification. Dysregulation of ISL2 has potential implications in developmental disorders and diseases involving neural and pancreatic tissues. Ongoing research aims to further elucidate its functions and potential as a therapeutic target in developmental biology and disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ISL2
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene ISL2
Gene Accession No. Q96A47
Gene Alias 3110001N10Rik; Insulin gene enhancer protein ISL-2; insulin related protein 2 (islet 2); ISL LIM homeobox 2; ISL2; Isl-2; ISL2 transcription factor, LIM/homeodomain, (islet-2); islet 2; islet-2
Gene Symbols ISL2
Host Species Rabbit
Immunogen Synthetic peptide directed towards the N-terminal of human ISL2.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 64843
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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