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Isopropylidene malonate, 97%, Thermo Scientific Chemicals

Catalog Number aaa1560314
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Quantity:
25 g
100 g
500 g
2033-24-1
C6H8O4
144.126
MFCD00006638
GXHFUVWIGNLZSC-UHFFFAOYSA-N
meldrum's acid, isopropylidene malonate, meldrums acid, 1,3-dioxane-4,6-dione, 2,2-dimethyl, sub-isopropyl malonate, 2,2-dimethyl-1,3-dioxan-4,6-dione, cycl-isopropylidene malonate, cyclic isopropylidene malonate, malonic acid cyclic isopropylidene ester, meldrum acid
16249
2,2-dimethyl-1,3-dioxane-4,6-dione
CC1(OC(=O)CC(=O)O1)C
2033-24-1
C6H8O4
144.126
MFCD00006638
GXHFUVWIGNLZSC-UHFFFAOYSA-N
meldrum's acid, isopropylidene malonate, meldrums acid, 1,3-dioxane-4,6-dione, 2,2-dimethyl, sub-isopropyl malonate, 2,2-dimethyl-1,3-dioxan-4,6-dione, cycl-isopropylidene malonate, cyclic isopropylidene malonate, malonic acid cyclic isopropylidene ester, meldrum acid
16249
2,2-dimethyl-1,3-dioxane-4,6-dione
CC1(OC(=O)CC(=O)O1)C

Isopropylidene malonate is an important reagent in synthetic chemistry and involved in the formation of new C-C bonds, rings, amides, esters, and acids. The presence of carbonyl groups at C-4 and C-6 positions favors the alkylation and acylation reactions due to its acidic nature. It is also employed as an antimicrobial agent. It is used in the preparation of 4-pyridyl-substituted heterocycles, 2-substituted indoles, isofraxidin and macrocyclic beta-keto lactones. Further, it is involved in the Knoevenagel condensation reaction with aldehydes.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Isopropylidene malonate is an important reagent in synthetic chemistry and involved in the formation of new C-C bonds, rings, amides, esters, and acids. The presence of carbonyl groups at C-4 and C-6 positions favors the alkylation and acylation reactions due to its acidic nature. It is also employed as an antimicrobial agent. It is used in the preparation of 4-pyridyl-substituted heterocycles, 2-substituted indoles, isofraxidin and macrocyclic beta-keto lactones. Further, it is involved in the Knoevenagel condensation reaction with aldehydes.

Solubility
Soluble in water. Slightly soluble in ethanol and chloroform.

Notes
Store in a cool place. Incompatible with strong oxidizing agents.
TRUSTED_SUSTAINABILITY
Melting Point 92°C to 96°C
Quantity 25 g
Beilstein 117310
Sensitivity Moisture sensitive
Merck Index 14,5817
Solubility Information Soluble in water. Slightly soluble in ethanol and chloroform.
Formula Weight 144.13
Percent Purity 98%
Chemical Name or Material Isopropylidene malonate
Hazard Category H315
Hazard Statement GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Precautionary Statement P264b-P280-P302+P352-P305+P351+P338-P332+P313-P362
DOTInformation Hazard Class: 9; Packaging Group: III
EINECSNumber 217-992-8
RTECSNumber JH0800000
TSCA Yes
Recommended Storage Ambient temperatures

RUO – Research Use Only

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