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Invitrogen™ ITCH Recombinant Rabbit Monoclonal Antibody (7I7B10)
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Catalog No. PIMA538170
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PIMA538170 100 μL
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Catalog No. PIMA538170 Supplier Invitrogen™ Supplier No. MA538170
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Description

Rabbit Recombinant Monoclonal Antibody

Positive Samples: HeLa, 293T, Raji, NIH/3T3, C6, Mouse lung Immunogen sequence: MSDSGSQLGS MGSLTMKSQL QITVISAKLK ENKKNWFGPS PYVEVTVDGQ SKKTEKCNNT NSPKWKQPLT VIVTPVSKLH FRVWSHQTLK SDVLLGTAAL.

Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ITCH
Applications ELISA, Western Blot
Classification Recombinant Monoclonal
Clone 7I7B10
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene ITCH
Gene Accession No. Q8C863, Q96J02
Gene Alias 6720481N21Rik; 8030492O04Rik; A130065M08; ADMFD; AIF4; AIP4; atrophin-1 interacting protein 4; Atrophin-1-interacting protein 4; C230047C07Rik; dJ468O1.1; E3 ubiquitin-protein ligase Itchy; E3 ubiquitin-protein ligase Itchy homolog; HECT-type E3 ubiquitin transferase Itchy homolog; ITCH; itch E3 ubiquitin ligase; itchy E3 ubiquitin protein ligase; itchy E3 ubiquitin protein ligase homolog; itchy, E3 ubiquitin protein ligase; NAPP1; NFE2-associated polypeptide 1
Gene Symbols ITCH
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ITCH (Q96J02).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16396, 311567, 83737
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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