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Tocris Bioscience™ ITD 1

Selective inhibitor of TGF-β signaling; induces cardiomyocyte differentiation in ESCs

Supplier: Tocris Bioscience™ 5068/10

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Catalog No. 50-681-0

$342.50 / Each of 1

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Description

ITD 1 is a selective inhibitor of TGF-β signaling (IC50 = 0.85 μM); displays little or no inhibition of activin, Wnt or BMP signaling pathways. Induces proteasomal degradation of the TGF-β type II receptor. Inhibits TGF-β-induced mesoderm formation from mouse embryonic stem cells (ESCs) during early differentiation; selectively promotes the differentiation of ESCs to cardiomyocytes in vitro between days 3-5. Does not induce differentiation of vascular smooth muscle cells or endothelial cells.

Specifications

Purity	>98%
Quantity	10 mg
Molecular Weight (g/mol)	415.52

Content And Storage	-20°C
Product Type	ITD 1
Inhibitors	ITD 1

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Tocris Bioscience™ ITD 1

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