Tocris Bioscience™ ITD 1 

Selective inhibitor of TGF-β signaling; induces cardiomyocyte differentiation in ESCs

Manufacturer:  Tocris Bioscience™ 5068/10

Catalog No. 50-681-0

Description

Selective inhibitor of TGF-β signaling (IC50 = 0.85 μM); displays little or no inhibition of activin, Wnt or BMP signaling pathways. Induces proteasomal degradation of the TGF-β type II receptor. Inhibits TGF-β-induced mesoderm formation from mouse embryonic stem cells (ESCs) during early differentiation; selectively promotes the differentiation of ESCs to cardiomyocytes in vitro between days 3-5. Does not induce differentiation of vascular smooth muscle cells or endothelial cells.

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Specifications

• Product Type: ITD 1
• Purity: >98
• Quantity: 10mg

• Inhibitors: ITD 1
• Molecular Weight: 415.52
• Storage Requirements: Store at -20°C

For Research Use Only