ITFG2 Monoclonal Antibody (OTI 3B3), TrueMAB™, OriGene

Catalog No.	Quantity
50-167-4025	100 μL
50-254-1146	30 μL

Catalog No. 50-167-4025 Supplier OriGene Supplier No. TA503052

Description

Mouse Monoclonal Antibody

As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.

Specifications

• Antigen: ITFG2
• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
• Classification: Monoclonal
• Clone: OTI 3B3
• Concentration: 0.33 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: ITFG2
• Gene Accession No.: Q969R8
• Gene Alias: FGGAP1, MDS028
• Gene Symbols: ITFG2
• Host Species: Mouse
• Immunogen: Full length human recombit protein of human ITFG2 produced in HEK293T cell.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 55846
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1