ITFG2 Monoclonal Antibody (OTI3A2), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA503051

Catalog No. 50-167-4024

Description

As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.

Specifications

• Antigen: ITFG2
• Classification: Monoclonal
• Concentration: 0.4 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q969R8
• Gene Symbols: ITFG2
• Immunogen: Full length human recombit protein of human ITFG2 produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence
• Clone: OTI3A2
• Conjugate: Unconjugated
• Gene: ITFG2
• Gene Alias: FGGAP1, MDS028
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55846
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid