Invitrogen™ ITFG2 Polyclonal Antibody

Catalog No.	Quantity
PIPA530764	100 μL

Catalog No. PIPA530764 Supplier Invitrogen™ Supplier No. PA530764

Description

Rabbit Polyclonal Antibody

Recommended positive controls: A549. Predicted reactivity: Mouse (90%), Rat (90%), Chimpanzee (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.

Specifications

• Antigen: ITFG2
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene: ITFG2
• Gene Accession No.: Q969R8
• Gene Alias: 2700050P07Rik; AI646725; integrin alpha FG-GAP repeat containing 2; integrin-alpha FG-GAP repeat-containing protein 2; integrin-alpha FG-GAP repeat-containing protein 2; KICSTOR complex protein ITFG2; ITFG2; KICSTOR complex protein ITFG2; MDS028; RGD1311944
• Gene Symbols: ITFG2
• Host Species: Rabbit
• Immunogen: Recombinant protein encompassing a sequence within the center region of human MDS028. The exact sequence is proprietary.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 55846
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG