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Invitrogen™ ITFG2 Polyclonal Antibody
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Catalog No. PIPA558484
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100 μL
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PIPA558484 100 μL
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Catalog No. PIPA558484 Supplier Invitrogen™ Supplier No. PA558484
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: AILLCTWKKD TGSPPASEGP TDGSRETPAA RDVVLHQTSG RIHNKNVSTH LIGNIKQGHG TESSGSGLFA LCTLDGTLKL MEEMEEADKL LWSV Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 84%.

As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ITFG2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ITFG2
Gene Accession No. Q969R8
Gene Alias 2700050P07Rik; AI646725; integrin alpha FG-GAP repeat containing 2; integrin-alpha FG-GAP repeat-containing protein 2; integrin-alpha FG-GAP repeat-containing protein 2; KICSTOR complex protein ITFG2; ITFG2; KICSTOR complex protein ITFG2; MDS028; RGD1311944
Gene Symbols ITFG2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ITFG2. Recombinant protein control fragment (Product #RP-97673).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55846
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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