Invitrogen™ ITFG2 Polyclonal Antibody

Catalog No.	Quantity
FEPA5145078	100 μL

Catalog No. FEPA5145078 Supplier Invitrogen™ Supplier No. PA5145078

Description

Rabbit Polyclonal Antibody

Immunogen sequence: GHEEVVACAW DGQTYIIDHN RTVVRFQVDE NIRAFCAGLY ACKEGRNSPC LVYVTFNQKI YVYWEVQLER MESTNLVKLL ETKPEYHSLL QELGVDPDDL Antigen sequence identity: Mouse 92%; Rat 94%.

As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.

Specifications

• Antigen: ITFG2
• Applications: Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.05 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: ITFG2
• Gene Accession No.: Q969R8
• Gene Alias: 2700050P07Rik; AI646725; integrin alpha FG-GAP repeat containing 2; integrin-alpha FG-GAP repeat-containing protein 2; integrin-alpha FG-GAP repeat-containing protein 2; KICSTOR complex protein ITFG2; ITFG2; KICSTOR complex protein ITFG2; MDS028; RGD1311944
• Gene Symbols: ITFG2
• Host Species: Rabbit
• Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 319-418. Recombinant protein control fragment (Product #RP-109821).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 55846
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Format: Liquid
• Isotype: IgG