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Invitrogen™ ITGA2 Recombinant Rabbit Monoclonal Antibody (7O9H6)
Rabbit Recombinant Monoclonal Antibody
Supplier: Invitrogen™ MA535243
Description
Immunogen sequence: GTFASSTFQT VQLTAAAEIN TYNPEIYVIE DNTVTIPLMI MKPDEKAEVP TGVIIGSIIA GILLLLALVA ILWKLGFFKR KYEKMTKNPD EIDETTELSS.
CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a glycoprotein with molecular weight of 150 kD, and it complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex. VLA-2 is an extracellular receptor for laminin, collagen, and fibronectin, and interaction with its ligands results in the activation of intracellular signaling pathways. It has reported roles in VEGF-induced angiogenesis in vivo, as well as adhesion and lymphocyte activation. CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, and epithelial cells. It is also expressed on adaptive immune cells such as T and B cells, specifically on a subset of CD4+ T cells in the spleen, on intraepithelial and lamina propria lymphocytes in the intestine, as well as on a population of peripheral CD4+ type 1 T regulatory (Tr1) cells that co-express LAG-3.
Specifications
ITGA2 | |
Recombinant Monoclonal | |
0.8 mg/mL | |
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3 | |
P17301, Q62469 | |
Itga2 | |
A synthetic peptide corresponding to a sequence within amino acids 1082-1181 of human Integrin alpha 2 (ITGA2/CD49b) (P17301). | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
ELISA, Immunohistochemistry (Paraffin), Western Blot | |
7O9H6 | |
Unconjugated | |
Itga2 | |
alpha 2 subunit of VLA-2 receptor; BDPLT9; BR; CD49 antigen-like family member B; CD49B; Collagen receptor; DX5; GPIa; HPA-5; human platelet alloantigen system 5; integrin alpha 2; integrin alpha-2; integrin subunit alpha 2; integrin, alpha 2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Itga2; platelet antigen Br; platelet glycoprotein GPIa; platelet membrane glycoprotein Ia; very late activation protein 2 receptor, alpha-2 subunit; VLA-2; VLA2 receptor; VLA-2 receptor, alpha 2 subunit; VLA-2 subunit alpha; VLAA2 | |
Rabbit | |
Affinity Chromatography | |
RUO | |
16398, 170921, 3673 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
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