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Description
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Specifications
Specifications
| Antigen | ITGAL |
| Applications | Flow Cytometry, Immunofluorescence |
| Classification | Monoclonal |
| Clone | 4A122 |
| Conjugate | FITC |
| Description | Mouse monoclonal antibody raised against human ITGAL. |
| Dilution | Flow cytometry Immunofluorescence The optimal working dilution should be determined by the end user. |
| Formulation | In PBS, pH 7.4 (0.09% sodium azide, 0.2% BSA) |
| Gene Alias | CD11A/LFA-1/LFA1A |
| Gene Symbols | ITGAL |
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