Invitrogen™ ITGB1BP2 Monoclonal Antibody (308705)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA524025

Catalog No. PIMA524025

Description

Reconstitute at 0.5 mg/mL in sterile PBS.

Integrin beta-1 binding protein 2 (ITGB1BP2), commonly referred to as Melusin, is a gene located on human chromosome 8p21.3. ITGB1BP2 is known for its role in cardiac muscle function, encoding a protein that interacts with integrin β1, which is essential for integrin signaling pathways. This gene is implicated in hypertrophic cardiomyopathy and dilated cardiomyopathy, conditions that affect heart muscle structure and function. ITGB1BP2 gene variations have been observed in families with hypertension or primary hypertrophic cardiomyopathy, although clear genotype/phenotype correlations were not conclusively established. Notably, a specific missense mutation in ITGB1BP2, involving alanine-to-glycine substitution at position 313, has been identified in patients with dilated cardiomyopathy. Melusin, the protein encoded by ITGB1BP2, plays a crucial role in mechanotransduction processes, influencing cellular responses to mechanical stress, which is particularly important in cardiac tissue adaptation and repair mechanisms.

Specifications

• Antigen: ITGB1BP2
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q9UKP3
• Gene Symbols: ITGB1BP2
• Immunogen: E. coli-derived recombinant human Melusin Ser2-Glu347.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Immunohistochemistry, Western Blot
• Clone: 308705
• Conjugate: Unconjugated
• Gene: ITGB1BP2
• Gene Alias: Chordc3; integrin beta 1 binding protein (melusin) 2; integrin beta 1 binding protein 2; integrin beta-1-binding protein 2; integrin subunit beta 1 binding protein 2; ITGB1BP; Itgb1bp2; Melusin; MGC119214; MSTP015; RGD1565015
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 26548
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized