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Invitrogen™ ITGB1BP2 Monoclonal Antibody (3G9)
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Catalog No. PIMA521660
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100 μg
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Catalog No. Quantity
PIMA521660 100 μg
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Catalog No. PIMA521660 Supplier Invitrogen™ Supplier No. MA521660
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Description

Mouse Monoclonal Antibody

Peptide Sequence: KASQTELHVH IVFDGNRVFQ AQMKLWGVIN VEQSSVFLMP SRVEISLVKA DPGSWAQLEH PDALAKKARA GVVL.

Integrin beta-1 binding protein 2 (ITGB1BP2), commonly referred to as Melusin, is a gene located on human chromosome 8p21.3. ITGB1BP2 is known for its role in cardiac muscle function, encoding a protein that interacts with integrin β1, which is essential for integrin signaling pathways. This gene is implicated in hypertrophic cardiomyopathy and dilated cardiomyopathy, conditions that affect heart muscle structure and function. ITGB1BP2 gene variations have been observed in families with hypertension or primary hypertrophic cardiomyopathy, although clear genotype/phenotype correlations were not conclusively established. Notably, a specific missense mutation in ITGB1BP2, involving alanine-to-glycine substitution at position 313, has been identified in patients with dilated cardiomyopathy. Melusin, the protein encoded by ITGB1BP2, plays a crucial role in mechanotransduction processes, influencing cellular responses to mechanical stress, which is particularly important in cardiac tissue adaptation and repair mechanisms.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ITGB1BP2
Applications ELISA, Western Blot
Classification Monoclonal
Clone 3G9
Concentration 0.32 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.4
Gene ITGB1BP2
Gene Accession No. Q9UKP3
Gene Alias Chordc3; integrin beta 1 binding protein (melusin) 2; integrin beta 1 binding protein 2; integrin beta-1-binding protein 2; integrin subunit beta 1 binding protein 2; ITGB1BP; Itgb1bp2; Melusin; MGC119214; MSTP015; RGD1565015
Gene Symbols ITGB1BP2
Host Species Mouse
Immunogen ITGB1BP2 (NP_036410, 246 a.a. ~ 319 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26548
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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