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Invitrogen™ ITGB1BP2 Polyclonal Antibody
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Catalog No. PIPA5103446
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PIPA5103446 100 μL
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Catalog No. PIPA5103446 Supplier Invitrogen™ Supplier No. PA5103446
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total ITBP2.

Integrin beta-1 binding protein 2 (ITGB1BP2), commonly referred to as Melusin, is a gene located on human chromosome 8p21.3. ITGB1BP2 is known for its role in cardiac muscle function, encoding a protein that interacts with integrin β1, which is essential for integrin signaling pathways. This gene is implicated in hypertrophic cardiomyopathy and dilated cardiomyopathy, conditions that affect heart muscle structure and function. ITGB1BP2 gene variations have been observed in families with hypertension or primary hypertrophic cardiomyopathy, although clear genotype/phenotype correlations were not conclusively established. Notably, a specific missense mutation in ITGB1BP2, involving alanine-to-glycine substitution at position 313, has been identified in patients with dilated cardiomyopathy. Melusin, the protein encoded by ITGB1BP2, plays a crucial role in mechanotransduction processes, influencing cellular responses to mechanical stress, which is particularly important in cardiac tissue adaptation and repair mechanisms.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ITGB1BP2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ITGB1BP2
Gene Accession No. Q9R000, Q9UKP3
Gene Alias Chordc3; integrin beta 1 binding protein (melusin) 2; integrin beta 1 binding protein 2; integrin beta-1-binding protein 2; integrin subunit beta 1 binding protein 2; ITGB1BP; Itgb1bp2; Melusin; MGC119214; MSTP015; RGD1565015
Gene Symbols ITGB1BP2
Host Species Rabbit
Immunogen A synthesized peptide derived from human ITGB1BP2(Accession Q9UKP3), corresponding to amino acid residues M1-S41.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26548, 26549
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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