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Description
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq]
Specifications
Specifications
| Antigen | ITGB2 |
| Applications | Immunohistochemistry (PFA fixed), Western Blot |
| Classification | Monoclonal |
| Clone | 534CT6.2.1 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against partial recombinant human ITGB2. |
| Dilution | Immunohistochemistry (1:25) Western Blot (1:100-1:500) The optimal working dilution should be determined by the end user. |
| Formulation | In PBS (0.09% sodium azide) |
| Gene Alias | CD18/LAD/LCAMB/LFA-1/MAC-1/MF17/MFI7 |
| Gene Symbols | ITGB2 |
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