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Invitrogen™ ITGB3BP Polyclonal Antibody
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Catalog No. PIPA5100723
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PIPA5100723 100 μL
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Catalog No. PIPA5100723 Supplier Invitrogen™ Supplier No. PA5100723
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total CENPR.

ITGB3BP is a transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. It induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. ITGB3BP may also act as an inhibitor of cyclin A-associated kinase. ITGB3BP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ITGB3BP
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ITGB3BP
Gene Accession No. Q13352, Q9CQ82
Gene Alias 4930471O16Rik; AU022583; beta 3 endonexin; beta-3-endonexin; beta3-endonexin; Cenpr; CENP-R; Centromere protein R; HSU37139; integrin beta 3 binding protein (beta3-endonexin); integrin beta-3-binding protein; integrin subunit beta 3 binding protein; Itgb3bp; Nrif3; Nuclear receptor-interacting factor 3; TAP20
Gene Symbols ITGB3BP
Host Species Rabbit
Immunogen A synthesized peptide derived from human ITGB3BP(Accession Q13352), corresponding to amino acid residues T36-F86.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23421, 67733
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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