Invitrogen™ ITGB3BP Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5100723

Catalog No. PIPA5100723

Description

Antibody detects endogenous levels of total CENPR.

ITGB3BP is a transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. It induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. ITGB3BP may also act as an inhibitor of cyclin A-associated kinase. ITGB3BP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

Specifications

• Antigen: ITGB3BP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ITGB3BP
• Gene Alias: 4930471O16Rik; AU022583; beta 3 endonexin; beta-3-endonexin; beta3-endonexin; Cenpr; CENP-R; Centromere protein R; HSU37139; integrin beta 3 binding protein (beta3-endonexin); integrin beta-3-binding protein; integrin subunit beta 3 binding protein; Itgb3bp; Nrif3; Nuclear receptor-interacting factor 3; TAP20
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23421, 67733
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q13352, Q9CQ82
• Gene Symbols: ITGB3BP
• Immunogen: A synthesized peptide derived from human ITGB3BP(Accession Q13352), corresponding to amino acid residues T36-F86.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov