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Invitrogen™ ITGB5 Polyclonal Antibody
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Catalog No. PIPA5120815
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100 μL
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PIPA5120815 100 μL
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Catalog No. PIPA5120815 Supplier Invitrogen™ Supplier No. PA5120815
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Description

Rabbit Polyclonal Antibody

Positive test controls include: Mouse brain, Mouse kidney, Mouse liver, Rat brain, Rat liver. The target is usually found in the following locations: Membrane, Single-pass type I membrane protein. Immunogen sequence: SPGYLGTRCE CQDGENQSVY QNLCREAEGK PLCSGRGDCS CNQCSCFESE FGKIYGPFCE CDNFSCARNK GVLCSGHGEC HCGECKCHAG YIGDNCNCST DISTCRGRDG QICSERGHCL CGQCQCTEPG AFGEMCEKCP TCPDACSTKR DCVECLLLHS GKPDNQTCHS LCRDEVITWV DTIVKDDQEA VLCFYKTAKD CVMMFTYVEL PSGKSNLTVL REPECGNTPN A.

Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around 22 different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell-surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in-groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N-terminal extracellular domain that binds the ECM ligand and a small C-terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ITGB5
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.42 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Itgb5
Gene Accession No. O70309, P18084
Gene Alias [b]5; [b]-5; [b]5A; [b]5B; AA475909; AI874634; beta5; beta-5; CD61; ESTM23; FLJ26658; GP3A; GPIIIa; I79_000655; integrin beta 5; integrin beta-5; integrin subunit beta 5; integrin, beta 5; ITGB5; RGD1563276; testis secretory sperm-binding protein Li 217p
Gene Symbols Itgb5
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 490-720 of human ITGB5 (NP_002204.2).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16419, 257645, 3693
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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