Invitrogen™ ITGB5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA517260

Catalog No. PIPA517260

Description

It is not recommended to aliquot this antibody.

Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around 22 different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell-surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in-groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N-terminal extracellular domain that binds the ECM ligand and a small C-terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function.

Specifications

• Antigen: ITGB5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Itgb5
• Gene Alias: [b]5; [b]-5; [b]5A; [b]5B; AA475909; AI874634; beta5; beta-5; CD61; ESTM23; FLJ26658; GP3A; GPIIIa; I79_000655; integrin beta 5; integrin beta-5; integrin subunit beta 5; integrin, beta 5; ITGB5; RGD1563276; testis secretory sperm-binding protein Li 217p
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 3693
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: 60 μg/mL
• Formulation: 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
• Gene Accession No.: P18084
• Gene Symbols: Itgb5
• Immunogen: Synthetic peptide corresponding to residues surrounding Lys789 of human integrin β5 protein.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov