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Invitrogen™ ITGB5 Polyclonal Antibody
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Catalog No. PIPA5118499
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100 μL
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PIPA5118499 100 μL
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Catalog No. PIPA5118499 Supplier Invitrogen™ Supplier No. PA5118499
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total Integrin beta 5.

Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around 22 different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell-surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in-groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N-terminal extracellular domain that binds the ECM ligand and a small C-terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ITGB5
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Itgb5
Gene Accession No. O70309, P18084
Gene Alias [b]5; [b]-5; [b]5A; [b]5B; AA475909; AI874634; beta5; beta-5; CD61; ESTM23; FLJ26658; GP3A; GPIIIa; I79_000655; integrin beta 5; integrin beta-5; integrin subunit beta 5; integrin, beta 5; ITGB5; RGD1563276; testis secretory sperm-binding protein Li 217p
Gene Symbols Itgb5
Host Species Rabbit
Immunogen A synthesized peptide derived from human ITGB5(Accession P18084), corresponding to amino acid residues A726-K776.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16419, 257645, 3693
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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