Invitrogen™ ITIH1 (Cleaved Asp672) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA537430

Catalog No. PIPA537430

Description

This antibody detects endogenous protein at a molecular weight of 71 and 101 kDa. Purity is >95% by SDS-PAGE.

The inter-alpha trypsin inhibitor (ITI) family is a group of structurally related plasma serine protease inhibitors synthesized in the liver and built up from different combinations of three highly homologous heavy chains (ITI-H1, ITI-H2 and ITI-H3) and one light chain (Bikunin). A fourth member of the ITI family, ITI-H4 (also known as I a IH4P) harbors a Pro-rich region (PRR) in its C-terminus. ITI is a glycoprotein composed of three polypeptides linked by chondroitin sulphate: two heavy chains, ITI-H1 and ITI-H2, and Bikunin. Bikunin confers the protease-inhibitor function of ITI. The heavy chains of the ITI family, designated as SHAPs (for serum-derived hyaluronan-associated proteins), bind covalently to hyaluronic acid (HA), resulting in pericellular matrix stabilization. ITI-H1 contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells. Although ITI-H1, ITI-H3 and Bikunin have antitumoral and antimetastatic properties in the cell, they are also associated with malignant transformation of lung tissue. ITI-H1 and ITI-H2 are associated with calcium oxalate stone formation in kidney and urine.

Specifications

• Antigen: ITIH1 (Cleaved Asp672)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ITIH1
• Gene Alias: H1P; IATIH; IGHEP1; inter-alpha (globulin) inhibitor, H1 polypeptide; inter-alpha trypsin inhibitor, heavy chain 1; inter-alpha-inhibitor heavy chain 1; inter-alpha-trypsin inhibitor complex component III; inter-alpha-trypsin inhibitor heavy chain 1; inter-alpha-trypsin inhibitor heavy chain H1; Intin1; ITI heavy chain H1; ITIH; ITIH1; Itih-1; ITI-HC1; Serum-derived hyaluronan-associated protein; SHAP
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16424, 306251, 3697
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P19827, Q61702
• Gene Symbols: ITIH1
• Immunogen: Synthetic peptide corresponding to amino acids 650-700 of human ITI-H1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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