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Invitrogen™ ITIH1 (Cleaved Asp672) Polyclonal Antibody
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Catalog No. PIPA537430
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PIPA537430 100 μL
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Catalog No. PIPA537430 Supplier Invitrogen™ Supplier No. PA537430
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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 71 and 101 kDa. Purity is >95% by SDS-PAGE.

The inter-alpha trypsin inhibitor (ITI) family is a group of structurally related plasma serine protease inhibitors synthesized in the liver and built up from different combinations of three highly homologous heavy chains (ITI-H1, ITI-H2 and ITI-H3) and one light chain (Bikunin). A fourth member of the ITI family, ITI-H4 (also known as I a IH4P) harbors a Pro-rich region (PRR) in its C-terminus. ITI is a glycoprotein composed of three polypeptides linked by chondroitin sulphate: two heavy chains, ITI-H1 and ITI-H2, and Bikunin. Bikunin confers the protease-inhibitor function of ITI. The heavy chains of the ITI family, designated as SHAPs (for serum-derived hyaluronan-associated proteins), bind covalently to hyaluronic acid (HA), resulting in pericellular matrix stabilization. ITI-H1 contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells. Although ITI-H1, ITI-H3 and Bikunin have antitumoral and antimetastatic properties in the cell, they are also associated with malignant transformation of lung tissue. ITI-H1 and ITI-H2 are associated with calcium oxalate stone formation in kidney and urine.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ITIH1 (Cleaved Asp672)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene ITIH1
Gene Accession No. P19827, Q61702
Gene Alias H1P; IATIH; IGHEP1; inter-alpha (globulin) inhibitor, H1 polypeptide; inter-alpha trypsin inhibitor, heavy chain 1; inter-alpha-inhibitor heavy chain 1; inter-alpha-trypsin inhibitor complex component III; inter-alpha-trypsin inhibitor heavy chain 1; inter-alpha-trypsin inhibitor heavy chain H1; Intin1; ITI heavy chain H1; ITIH; ITIH1; Itih-1; ITI-HC1; Serum-derived hyaluronan-associated protein; SHAP
Gene Symbols ITIH1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to amino acids 650-700 of human ITI-H1.
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16424, 306251, 3697
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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