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Invitrogen™ ITIH4 Monoclonal Antibody (CL1858)
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Catalog No. PIMA524630
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100 μL
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PIMA524630 100 μL
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Catalog No. PIMA524630 Supplier Invitrogen™ Supplier No. MA524630
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Description

Mouse Monoclonal Antibody

Immunogen sequence: LAYSFVTPLT SMVVTKPDDQ EQSQVAEKPM EGESRNRNVH SAGAAGSRMN FRPGVLSSRQ LGLPGPPDVP DHAAYHPFRR LAILPASAPP ATSNPDPAVS RVMNMKIEET TMTTQTPA Highest antigen sequence identity to the following orthologs: Mouse - 35%, Rat - 36%. Binds to an epitope located within the peptide sequence LSSRQLGLPGPPDVP as determined by overlapping synthetic peptides.

The inter-alpha-trypsin inhibitor (ITI, I-alpha-I) family is a classic example of protein-glycosaminoglycoprotein (PGP) complexes. They occur constitutively in plasma at relatively high concentrations and results from alternating combinations of three kinds of heavy chains with a common light chain called the bikunin proteoglycan. Bikunin has two proteinase inhibotor domains and belongs to the Kunitz-type protease inhibitor family; it displays an inhibitory activity against trypsin, leukocyte elastase and plasmin. The heavy chains do not have any protease inhibitory properties but have the capacity to interact in vitro and in vivo with hyaluronic acid and this binding promotes the stability of the extra-cellular matrix. The ITI protein family is suspected of playing a key role in the extra-cellular matrix biology.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ITIH4
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone CL1858
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ITIH4
Gene Accession No. Q14624
Gene Alias 35 kDa inter-alpha-trypsin inhibitor heavy chain H4; 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; DKFZp686G21125; Gp120; H4P; IHRP; Inter alpha-trypsin inhibitor, heavy chain 4; inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein); inter-alpha-inhibitor heavy chain 4; inter-alpha-trypsin inhibitor family heavy chain-related protein; inter-alpha-trypsin inhibitor heavy chain 4; inter-alpha-trypsin inhibitor heavy chain family member 4; inter-alpha-trypsin inhibitor heavy chain family, member 4; inter-alpha-trypsin inhibitor heavy chain H4; inter-alpha-trypsin inhibitor, heavy chain-like, 1; ITI heavy chain H4; Itih4; Itih-4; ITI-HC4; ITIHL1; PK120; PK-120; Plasma kallikrein sensitive glycoprotein 120; plasma kallikrein-sensitive glycoprotein 120; PRO1851
Gene Symbols ITIH4
Host Species Mouse
Immunogen Recombinant protein fragment of Human ITIH4 (Product #RP-100485)
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3700
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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