ITM2B Monoclonal Antibody (OTI1C11), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA502734

Catalog No. 50-167-3757

Description

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.

Specifications

• Antigen: ITM2B
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q9Y287
• Gene Symbols: ITM2B
• Immunogen: Full length human recombit protein of human ITM2B produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1C11
• Conjugate: Unconjugated
• Gene: ITM2B
• Gene Alias: ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD, RDGCA, imBRI2
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9445
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid