Invitrogen™ ITM2B Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA519074

Catalog No. PIPA519074

Description

This antibody is predicted to react with bovine, mouse and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 8,000.

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.

Specifications

• Antigen: ITM2B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ITM2B
• Gene Alias: ABRI; ABri/ADan amyloid peptide; ABri23; AI256040; Bri; BRI2; BRI2 ICD; BRI2 intracellular domain; BRI2, membrane form; Bri2-23; Bri23 peptide; BRI2C, soluble form; Bricd2b; BRICHOS domain containing 2B; C-terminal peptide; D14Sel6; E25B; E25BMM; E3-16; FBD; imBRI2; Immature BRI2; integral membrane protein 2B; Integral membrane protein 2B (E25B protein); ITM2B; Mature BRI2; mBRI2; OTTHUMP00000018394; P23 peptide; Protein E25B; RDGCA; RP11-196P14.1; Transmembrane protein BRI
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 9445
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9Y287
• Gene Symbols: ITM2B
• Immunogen: Synthetic peptide sequence (HDKETYKLQRRETIK) corresponding to the internal amino acids of ITM2B (aa 224-239).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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