Invitrogen™ ITM2B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA531441

Catalog No. PIPA531441

Description

Recommended positive controls: HepG2, HCT116, mouse brain, rat brain. Predicted reactivity: Mouse (95%), Rat (96%), Pig (95%), Sheep (96%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (96%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.

Specifications

• Antigen: ITM2B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ITM2B
• Gene Alias: ABRI; ABri/ADan amyloid peptide; ABri23; AI256040; Bri; BRI2; BRI2 ICD; BRI2 intracellular domain; BRI2, membrane form; Bri2-23; Bri23 peptide; BRI2C, soluble form; Bricd2b; BRICHOS domain containing 2B; C-terminal peptide; D14Sel6; E25B; E25BMM; E3-16; FBD; imBRI2; Immature BRI2; integral membrane protein 2B; Integral membrane protein 2B (E25B protein); ITM2B; Mature BRI2; mBRI2; OTTHUMP00000018394; P23 peptide; Protein E25B; RDGCA; RP11-196P14.1; Transmembrane protein BRI
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16432, 290364, 9445
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.81 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: O89051, Q5XIE8, Q9Y287
• Gene Symbols: ITM2B
• Immunogen: Recombinant fragment corresponding to a region within amino acids 15 and 264 of Human ITM2B.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG