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Invitrogen™ ITM2B Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA583079
Description
Immunogen sequence: YFALQPDDVY YCGIKYIKDD VILNEPSADA PAALYQTIEE NIKIFEEEEV EFISVPVPEF ADSDPANIVH DFNKKLTAYL DLNLDKCYVI PLNTSIVMPP RNLLELLINI KAGTYLPQSY LIHEHMVITD RIENIDHLGF FIYRLCH.
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
Specifications
ITM2B | |
Polyclonal | |
Unconjugated | |
ITM2B | |
ABRI; ABri/ADan amyloid peptide; ABri23; AI256040; Bri; BRI2; BRI2 ICD; BRI2 intracellular domain; BRI2, membrane form; Bri2-23; Bri23 peptide; BRI2C, soluble form; Bricd2b; BRICHOS domain containing 2B; C-terminal peptide; D14Sel6; E25B; E25BMM; E3-16; FBD; imBRI2; Immature BRI2; integral membrane protein 2B; Integral membrane protein 2B (E25B protein); ITM2B; Mature BRI2; mBRI2; OTTHUMP00000018394; P23 peptide; Protein E25B; RDGCA; RP11-196P14.1; Transmembrane protein BRI | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
9445 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin), Immunocytochemistry | |
0.10 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q9Y287 | |
ITM2B | |
Recombinant protein corresponding to Human ITM2B. Recombinant protein control fragment (Product #RP-102188). | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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