Invitrogen™ ITM2C Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA530838

Catalog No. PIPA530838

Description

Recommended positive controls: HeLa. Predicted reactivity: Mouse (95%), Rat (97%), Pig (98%), Chicken (81%), Sheep (97%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.

Specifications

• Antigen: ITM2C
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ITM2C
• Gene Alias: 3110038L02Rik; BRI3; Bricd2c; BRICHOS domain containing 2C; cerebral protein 14; CT-BRI3; E25; E25C; hRPC.1050_D_4; hucep-14; Integral membrane protein 2C; integral membrane protein 3; Itm2c; ITM3; NPD018; PSEC0047; Transmembrane protein BRI3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 81618
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.7 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q9NQX7
• Gene Symbols: ITM2C
• Immunogen: Recombinant protein encompassing a sequence within the center region of human ITM2C. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov