Invitrogen™ ITPA Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA528483

Catalog No. PIPA528483

Description

Recommended positive controls: 293T, H1299, HeLaS3, HepG2, Molt-4, Raji. Predicted reactivity: Mouse (91%), Rat (92%), Xenopus laevis (80%), Chicken (81%), Bovine (92%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Specifications

• Antigen: ITPA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ITPA
• Gene Alias: 2010016I08Rik; AU020102; C20orf37; dJ794I6.3; HAMAP-Rule:MF_03148}; HLC14-06-P; inosine triphosphatase; inosine triphosphatase (nucleoside triphosphate pyrophosphatase); inosine triphosphatase {ECO:0000255; inosine triphosphate pyrophosphatase; inosine triphosphate pyrophosphatase {ECO:0000255; inosine triphosphate pyrophosphohydrolase; Itp; ITPA; ITPase; ITPase {ECO:0000255; My049; My049 protein; Non-canonical purine NTP pyrophosphatase; non-canonical purine NTP pyrophosphatase {ECO:0000255; non-standard purine NTP pyrophosphatase; non-standard purine NTP pyrophosphatase {ECO:0000255; NTPase; NTPase {ECO:0000255; nucleoside triphosphate pyrophosphatase; nucleoside-triphosphate diphosphatase; nucleoside-triphosphate diphosphatase {ECO:0000255; Nucleoside-triphosphate pyrophosphatase; nucleoside-triphosphate pyrophosphatase {ECO:0000255; OK/SW-cl.9; Putative oncogene protein hlc14-06-p
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3704
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q9BY32
• Gene Symbols: ITPA
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 194 of Human ITPase.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov