Invitrogen™ ITPRIPL1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA531770

Catalog No. PIPA531770

Description

Recommended positive controls: 293T, A431, Jurkat, Raji. Predicted reactivity: Mouse (90%), Rat (89%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The ITPRIPL1 (Inositol 1,4,5-Trisphosphate Receptor Interacting Protein-Like 1) gene encodes a protein implicated in T cell regulation by interacting with the CD3ε molecule. It is located on chromosome 6. The ITPRIPL1 protein acts as an inhibitory ligand for CD3ε, thereby modulating T cell activation in the tumor microenvironment. This interaction significantly reduces calcium influx and phosphorylation of ZAP70, which are critical steps in the T cell activation pathway. The downregulation of these processes by ITPRIPL1 suggests its role in immune response modulation and tumor immune evasion. Given its regulatory functions, ITPRIPL1 has become a subject of research for its potential implications in cancer immunotherapy and as a biomarker for diagnosing and prognosticating various cancers.

Specifications

• Antigen: ITPRIPL1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ITPRIPL1
• Gene Alias: inositol 1,4,5-triphosphate receptor-interacting protein-like 1; inositol 1,4,5-trisphosphate receptor interacting protein-like 1; inositol 1,4,5-trisphosphate receptor-interacting protein-like 1; ITPRIPL1; KIAA1754L
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 150771
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q6GPH6
• Gene Symbols: ITPRIPL1
• Immunogen: Recombinant protein encompassing a sequence within the Intracellular domain of human ITPRIPL1. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG