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Invitrogen™ ITPRIPL1 Polyclonal Antibody
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Catalog No. PIPA531770
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100 μL
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Catalog No. Quantity
PIPA531770 100 μL
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Catalog No. PIPA531770 Supplier Invitrogen™ Supplier No. PA531770
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431, Jurkat, Raji. Predicted reactivity: Mouse (90%), Rat (89%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The ITPRIPL1 (Inositol 1,4,5-Trisphosphate Receptor Interacting Protein-Like 1) gene encodes a protein implicated in T cell regulation by interacting with the CD3ε molecule. It is located on chromosome 6. The ITPRIPL1 protein acts as an inhibitory ligand for CD3ε, thereby modulating T cell activation in the tumor microenvironment. This interaction significantly reduces calcium influx and phosphorylation of ZAP70, which are critical steps in the T cell activation pathway. The downregulation of these processes by ITPRIPL1 suggests its role in immune response modulation and tumor immune evasion. Given its regulatory functions, ITPRIPL1 has become a subject of research for its potential implications in cancer immunotherapy and as a biomarker for diagnosing and prognosticating various cancers.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ITPRIPL1
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene ITPRIPL1
Gene Accession No. Q6GPH6
Gene Alias inositol 1,4,5-triphosphate receptor-interacting protein-like 1; inositol 1,4,5-trisphosphate receptor interacting protein-like 1; inositol 1,4,5-trisphosphate receptor-interacting protein-like 1; ITPRIPL1; KIAA1754L
Gene Symbols ITPRIPL1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the Intracellular domain of human ITPRIPL1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 150771
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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